This review systematically examines the literature and data on the prognostic significance of heat shock
proteins (heat shock protein - Hsp) Hsp27, Hsp60, Hsp70, Hsp90 in various cancers. Our analysis of the literature showed
that the existing data are contradictory with regard to the prognostic significance of Hsp. This result may be due to
biological differences of the carcinomas studied and methodological differences in the assessment of heat shock proteins.
Heat shock proteins play a significant role in the development of cancer, as they are highly expressed and thus allow
tumor cells to escape apoptotic death. Therefore, the inhibition of Hsps is currently an attractive potential therapeutic
approach against cancer.
Keywords: Cancer, heat shock proteins, Hsp27, Hsp60, Hsp70, Hsp90, prognostic markers.
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