Title:The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target
VOLUME: 14 ISSUE: 7
Author(s):Haleh Vosgha, Ali Salajegheh, Robert Anthony Smith and Alfred King-Yin Lam
Affiliation:Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia.
Keywords:Carcinoma, cancer, miRNA-205, microRNA, oncogene, tumour suppressor gene.
Abstract:Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its
aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic
miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival,
apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation,
migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All
these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a
therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in
different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.
