The Neuroprotective Role of Vesicular Monoamine Transporter 2 in Neurodegenerative Diseases

Author(s): Burak Yulug, Lutfu Hanoglu, Ertugrul Kilic

Journal Name: Medicinal Chemistry

Volume 11 , Issue 2 , 2015

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Graphical Abstract:


Neuropharmacological relation of religious belief supports the role of dopaminergic activation as the leading neurochemical feature. However, vesicular monoamine transporter-2 (VMAT-2) has been shown to be responsible for removing of neurotransmitters such as dopamine that may secondarily lead to a neuroprotective activity by different neurodegeneration models. Moreover, there are interesting data showing that VMAT-2 may play an important role during religious belief and experience. In the light of these findings, we aimed to review the preclinical and clinical neuroprotective data of Vesicular monoamine transporter (VMAT-2) in different neurodegenerative and neuropsychiatric diseases. In respect of rapidly increasing evidences about the neurobiological and neuroimaging correlates of religious belief, we hypothesized that there is a link between belief and neuroprotection.

Keywords: VMAT-2, neuroprotection, religious belief.

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Article Details

Year: 2015
Published on: 25 September, 2014
Page: [104 - 108]
Pages: 5
DOI: 10.2174/1573406410666140925151845
Price: $65

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