The Medical Lives of History`s Famous People

Indexed in: EBSCO

This eBook “ Medical Lives of History`s Famous People” highlights the consequences of numerous medical concerns of historical individuals. It also discusses in depth how the public lives of ...
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Hutchinson-Gilford Progeria Syndrome as an Inspiration for F. Scott Fitzgeraldʼs Fictional Character ʻBenjamin Buttonʼ

Pp. 3-10 (8)

William James Maloney


In 1886 Hutchinson-Gilford Progeria Syndrome (HGPS) first appeared in the medical literature. An individual with HGPS exhibits many physical characteristics and ailments which are usually associated with the elderly.

F. Scott Fitzgerald published, in 1921, a short story entitled ʻThe Curious Case of Benjamin Button.ʼ The central character of this story is born as an elderly man. It is postulated that Fitzgerald based his character on a real-life individual with HGPS. More importantly, it is theorized that medicine and society has viewed, in the past, these individuals incorrectly. These individuals might actually be experiencing true physical aging in a very accelerated manner.


Aging, atrophic skin, Benjamin Button, coxa valga, delayed tooth eruption, F. Scott Fitzgerald, farnesyltransferase inhibitors, genetics, Hutchinson- Gilford Progeria syndrome, hypertension, LMNA, mutation, progerin, prominent eyes, tipifarnib, transcription.


New York University College of Dentistry 345 First Avenue New York NY 10010 USA.