Abstract
Parkinson’s disease is a common neurodegenerative disease diagnosed by well established clinical motor symptoms. However, the disease also encompasses many nonmotor issues that can impact a myriad of processes such as cardiovascular status, gastrointestinal function, autonomic function, mood and sleep. These issues can be more debilitating and impactful on health status in part because of a lack of effective treatments. The pathophysiology of the disease process is under active investigation with postulated mechanisms involving both the central nervous system and the periphery. More in depth examination of the many nonmotor symptoms may aid in the discovery of the overarching pathological origin and progression of Parkinson’s disease. Examining the disease process from the perspective of nonmotor symptoms may also provide additional target pathways and potential drug development options not considered previously.
Keywords: Anxiety, autonomic failure, cognitive disorders, depression, nonmotor symptoms, Parkinson’s disease, sleep.
CNS & Neurological Disorders - Drug Targets
Title:New Targets for Treating the Underlying Pathophysiology and Nonmotor Aspects of Parkinson's Disease
Volume: 13 Issue: 7
Author(s): Jonathan T. Butler and Christopher Tolleson
Affiliation:
Keywords: Anxiety, autonomic failure, cognitive disorders, depression, nonmotor symptoms, Parkinson’s disease, sleep.
Abstract: Parkinson’s disease is a common neurodegenerative disease diagnosed by well established clinical motor symptoms. However, the disease also encompasses many nonmotor issues that can impact a myriad of processes such as cardiovascular status, gastrointestinal function, autonomic function, mood and sleep. These issues can be more debilitating and impactful on health status in part because of a lack of effective treatments. The pathophysiology of the disease process is under active investigation with postulated mechanisms involving both the central nervous system and the periphery. More in depth examination of the many nonmotor symptoms may aid in the discovery of the overarching pathological origin and progression of Parkinson’s disease. Examining the disease process from the perspective of nonmotor symptoms may also provide additional target pathways and potential drug development options not considered previously.
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Cite this article as:
Butler T. Jonathan and Tolleson Christopher, New Targets for Treating the Underlying Pathophysiology and Nonmotor Aspects of Parkinson's Disease, CNS & Neurological Disorders - Drug Targets 2014; 13 (7) . https://dx.doi.org/10.2174/1871527313666140917104850
DOI https://dx.doi.org/10.2174/1871527313666140917104850 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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