A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward
methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluated in vitro. Two
curcumin-biphenyl derivatives showed interesting growth inhibitory activities on different malignant melanoma cell lines
with IC50 ranging from 13 to 1 µM. Preliminary molecular modeling studies were carried out to evaluate conformations
and dihedral angles suitable for antiproliferative activity in hydroxylated biphenyls bearing a side aliphatic chain.
Keywords: Curcumin, dihedral angle, hydroxylated biphenyls, malignant melanoma, synthesis.
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