Frontiers in Anti-Infective Drug Discovery

Volume: 3

Indexed in: Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics ...
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In Silico Study Verifying Antiviral Activity of Proanthocyanidins with Special Reference to Dengue Virus

Pp. 317-338 (22)

Lakshmi Chandrasekaran, Koji Ichiyama, Vivian Feng Chen, Akiko Saito, Yoshiyuki Yoshinaka and Naoki Yamamoto

Abstract

Proanthocyanidins exist as a part of a particular group of polyphenolic compounds known as flavanols. They are commonly occurring plant metabolites generally available in many sources such as fruits, bark, leaves and seeds of plants. They possess monomers, oligomers and polymers of varying molecular sizes composed of flavan-3-ols that serve as the building blocks. These compounds have been reported to have anti-carcinogenic, anti-inflammatory, anti-allergic, antioxidant, antibacterial and antiviral properties in human beings. This review will primarily focus on the in silico and in vitro analyses that verify antiviral activity of proanthocyanidins against several viruses, primarily the dengue virus.

Keywords:

Antiviral activity, catechin, dengue virus, epicatechin, flavonoids, in silico, in vitro, proanthocyanidins.

Affiliation:

Translational ID Lab, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, #15-02 Centre for Translational Medicine (MD6), 117599 Singapore.