In Silico Study Verifying Antiviral Activity of Proanthocyanidins with Special Reference to Dengue Virus
Pp. 317-338 (22)
Lakshmi Chandrasekaran, Koji Ichiyama, Vivian Feng Chen, Akiko Saito, Yoshiyuki Yoshinaka and Naoki Yamamoto
Proanthocyanidins exist as a part of a particular group of polyphenolic
compounds known as flavanols. They are commonly occurring plant metabolites
generally available in many sources such as fruits, bark, leaves and seeds of plants.
They possess monomers, oligomers and polymers of varying molecular sizes composed
of flavan-3-ols that serve as the building blocks. These compounds have been reported
to have anti-carcinogenic, anti-inflammatory, anti-allergic, antioxidant, antibacterial and
antiviral properties in human beings. This review will primarily focus on the in silico
and in vitro analyses that verify antiviral activity of proanthocyanidins against several
viruses, primarily the dengue virus.
Antiviral activity, catechin, dengue virus, epicatechin, flavonoids, in
silico, in vitro, proanthocyanidins.
Translational ID Lab, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, #15-02 Centre for Translational Medicine (MD6), 117599 Singapore.