Newcastle Disease Virus as a Promising Vector against Infectious Diseases and as a Potential Agent against Cancers
Pp. 173-193 (21)
Xiaodong Zhang, Mingming Han, Chao Gao, Renfu Yin, Donald L. Reynolds, Dylan Frabutt, Liangxue Lai, Minhua Sun, Ying Chen, Xiang Li and Zhuang Ding
The continual emergence of viral pathogens highlights the need for effective
vaccine systems that can rapidly adapt to changing or novel pathogens. The use of
Newcastle disease virus (NDV)-based vector vaccines may be one of the most feasible
approaches for achieving protection against such pathogens. ND is one of the most
important infectious diseases of poultry. However, the use of this poultry pathogen as a
vaccine vector to offer protection against other pathogens has become of interest to
researchers worldwide. For example, a study has demonstrated that an NDV-based
influenza A virus (H5N1) vaccine could provide complete protection of chickens and
mice from lethal challenge of homologous and heterologous H5N1 avian influenza
viruses. Furthermore, naturally occurring strains of NDV have demonstrated oncolytic
therapeutic potency in preclinical and clinical studies. With the development of reverse
genetics technology, modifications of oncolytic NDVs resulting in increased targeting
and oncolytic potency become feasible. Such strategies may become a promising novel
therapeutic approach against cancers. Therefore, NDV can be used as a vaccine vector
to immunize against emerging or reemerging pathogens and may have great potential to
be used for cancer treatment in the future.
Newcastle disease virus, vaccine vector, reverse genetics, infectious
disease, cancer treatment.
College of Veterinary Medicine, Jilin University, No.5333 Xi’an Street, Changchun, 130062, China.