Optimizing Conventional Medical Therapies in Inflammatory Bowel Disease in 2014

Author(s): Anil Kumar Asthana, Miles P. Sparrow, Laurent Peyrin-Biroulet.

Journal Name: Current Drug Targets

Volume 15 , Issue 11 , 2014

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Abstract:

Goals of therapy for inflammatory bowel disease have advanced beyond symptom control to the normalization of biomarkers of inflammation, and mucosal healing in particular, with the expectation that this will change the natural history of these diseases. Concurrent with higher treatment expectations has come an expanded therapeutic armamentarium to achieve these goals, and a greater ability to optimize each therapeutic class to maximize therapeutic benefits and minimize unnecessary treatment failures. In addition to these advances has come the evolution of therapeutic drug monitoring which is increasingly being utilized to optimize the use of immunomodulators and biologic therapies in particular. This review will outline the principals of optimization of the conventional medical therapies available to the clinician today.

Keywords: Aminosalicylates, allopurinol, anti-tumor necrosis factor agents, corticosteroids, thiopurines, thioguanine nucleotides, therapeutic drug monitoring.

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Article Details

VOLUME: 15
ISSUE: 11
Year: 2014
Page: [1002 - 1010]
Pages: 9
DOI: 10.2174/1389450115666140915113503
Price: $65

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