Three series of novel bile acid conjugates with different –amino acid have been synthesized. The
synthesis of final compounds was accomplished with anhydride using ethyl chloroformate. The conjugation
was introduced via coupling of the bile acid anhydride with appropriately functionalized α-amino acid. Biological
evaluation of synthesized compounds was carried out in vitro for their antimicrobial and antifungal
properties against human pathogens. The bile acid conjugates 1g, 2g, 2h and 3g indicated 2–fold stronger antimicrobial
activity compared to ciprofloxacin. The final products were obtained in both high yield and purity.
The prepared conjugated bile acids were characterized by mass spectrometry, infrared spectroscopy and nuclear magnetic
resonance proton spectroscopy which are also discussed along with the thin–layer chromatographic properties.
Keywords: α-amino acids, antimicrobial activity, bile acids, conjugated bile acid, MIC values.
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