Abstract
The objective of the present study was to formulate bilayer matrix tablets containing aceclofenac as sustained release and paracetamol as immediate release using HPMC as the matrix forming polymer and the tablets were evaluated via in-vitro studies. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better effect when compared with marketed combination tablets. Tablets thus formulated provided sustained release of aceclofenac over a period of 12 h and paracetamol as immediate release within 30 min.
Keywords: Aceclofenac, bilayer tablet, immediate release, paracetamol, sustained release.
Drug Delivery Letters
Title:Formulation and in-vitro Evaluation of a Bilayer Matrix Tablet Containing Aceclofenac as Sustained Release and Paracetamol as Immediate Release
Volume: 4 Issue: 3
Author(s): Hamid Khan and Javed Ali
Affiliation:
Keywords: Aceclofenac, bilayer tablet, immediate release, paracetamol, sustained release.
Abstract: The objective of the present study was to formulate bilayer matrix tablets containing aceclofenac as sustained release and paracetamol as immediate release using HPMC as the matrix forming polymer and the tablets were evaluated via in-vitro studies. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better effect when compared with marketed combination tablets. Tablets thus formulated provided sustained release of aceclofenac over a period of 12 h and paracetamol as immediate release within 30 min.
Export Options
About this article
Cite this article as:
Khan Hamid and Ali Javed, Formulation and in-vitro Evaluation of a Bilayer Matrix Tablet Containing Aceclofenac as Sustained Release and Paracetamol as Immediate Release, Drug Delivery Letters 2014; 4 (3) . https://dx.doi.org/10.2174/2210303104666140909004155
DOI https://dx.doi.org/10.2174/2210303104666140909004155 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
Call for Papers in Thematic Issues
Nanomaterial Assisted Targeted Therapies for Chronic Disorders- Preclinical to Clinical Outcomes
In recent years, the integration of nanomaterials into therapeutic strategies has emerged as a promising avenue in the pursuit of more effective treatments for chronic disorders. This dynamic field, explored in the context of "Nanomaterial Assisted Targeted Therapies for Chronic Disorders - Preclinical to Clinical Outcomes," seeks to bridge the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Clinical Aspects of Melatonin in the Acute Coronary Syndrome
Current Vascular Pharmacology Plant-Derived Biomolecules and Drug Delivery Systems in the Treatment of Liver and Kidney Diseases
Current Pharmaceutical Design Glycyrrhetinic Acid Ammonium Loaded Microspheres Using Colocasia esculenta and Bombax ceiba mucilages: In Vitro and In Vivo Characterization
Current Drug Therapy Clinical Trial Update and Novel Therapeutic Approaches for Metastatic Prostate Cancer
Current Medicinal Chemistry Relations between GPR4 Expression, Microvascular Density (MVD) and Clinical Pathological Characteristics of Patients with Epithelial Ovarian Carcinoma (EOC)
Current Pharmaceutical Design Pharmacotherapies for Glaucoma
Current Molecular Medicine Silence of the Limbs: Pharmacological Symptomatic Treatment of Intermittent Claudication
Current Vascular Pharmacology Neurobiological Influences on Recovery from Traumatic Brain Injury: The Role of Genetic Polymorphisms
Current Pharmaceutical Design Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva
Current Pharmaceutical Design Apoptotic and Anti-Angiogenic Effects of Benzimidazole Compounds: Relationship with Oxidative Stress Mediated Ischemia/Reperfusion Injury in Rat Hind Limb
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Selenium and Autoimmune Diseases: A Review Article
Current Rheumatology Reviews Attacking HIV Provirus: Therapeutic Strategies to Disrupt Persistent Infection
Infectious Disorders - Drug Targets Spontaneous Adverse Drug Reaction Monitoring in a Tertiary Care Centre
Current Drug Safety Transthyretin Decrease in Plasma of MCI and AD Patients: Investigation of Mechanisms for Disease Modulation
Current Alzheimer Research Inflammation: A Multidimensional Insight on Natural Anti-Inflammatory Therapeutic Compounds
Current Medicinal Chemistry Experimental Study of Therapeutic Efficacy of the Topical Preparation «Kourochitin» in Skin Allergy
Letters in Drug Design & Discovery Hormone Replacement Therapy and Stroke
Current Vascular Pharmacology Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis
Current Medicinal Chemistry Editorial [Hot Topic: Current Strategies in Vascular Biology (Guest Editor: Elisabeth Deindl)]
Current Pharmaceutical Biotechnology Molecule of the Month
Current Topics in Medicinal Chemistry