The objective of the present study was to formulate bilayer matrix tablets containing aceclofenac as sustained
release and paracetamol as immediate release using HPMC as the matrix forming polymer and the tablets were evaluated
via in-vitro studies. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1%
w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated
UPLC-PDA method. In-vitro drug release from prepared tablets showed better effect when compared with marketed
combination tablets. Tablets thus formulated provided sustained release of aceclofenac over a period of 12 h and
paracetamol as immediate release within 30 min.
Keywords: Aceclofenac, bilayer tablet, immediate release, paracetamol, sustained release.
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