Mechanisms of Beta-Blockers Action in Patients with Heart Failure

Author(s): Sergej Prijic, Reiner Buchhorn

Journal Name: Reviews on Recent Clinical Trials

Volume 9 , Issue 2 , 2014

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Abstract:

Patients with chronic heart failure have prolonged sympathetic stimulation and subsequent worsening of the failing heart function. Beta-blockers (non-selective, cardio-selective, and non-selective with ancillary properties) counteract the effects of prolonged sympathetic stimulation. Beta-blocker therapy results in the improvement of the left ventricular systolic and diastolic function, reversal remodeling, heart rate control, effective prevention of the malignant arrhythmias, and lowering of the both cardiac afterload and preload in patients with chronic heart failure.

Keywords: Beta-blockers, mechanisms, childhood, heart failure.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2014
Page: [58 - 60]
Pages: 3
DOI: 10.2174/1574887109666140908125402
Price: $65

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