Therapeutic Angiogenesis: Recent and Future Prospects of Gene Therapy in Peripheral Artery Disease

Author(s): Michiko Tanaka, Kikuko Taketomi, Yoshikazu Yonemitsu

Journal Name: Current Gene Therapy

Volume 14 , Issue 4 , 2014

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer


Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.

Keywords: Angiogenesis, clinical trials, gene therapy, growth factor, peripheral artery disease, plasmid.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Page: [300 - 308]
Pages: 9
DOI: 10.2174/156652321404140902124838
Price: $65

Article Metrics

PDF: 33