Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic
angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase
clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an
overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic
growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights
into future directions from bench to bedside.
Keywords: Angiogenesis, clinical trials, gene therapy, growth factor, peripheral artery disease, plasmid.
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