A series of 4-methyl-7-O-substituted coumarins (3-12) was synthesized and evaluated for in vitro antimicrobial
activity against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), four Gram-negative bacteria
(Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris) and three fungal strains (Candida
albicans, Cryptococcus terreus and Saccharomyces cerevisiae) by two-fold serial dilution technique. The results of
bioactive assay showed that some of the synthesized coumarins displayed comparable or even better antibacterial and
antifungal activities against tested strains in comparison with reference drugs erythromycin, novobiocin and amphotericin
B. Compound 9 showed potent antimicrobial activities against seven of the nine microbial strains examined in this study
with MIC values ranging between 1.09 and 25 µg/mL and was the most active compound of the series. The present work
also describes the effect of substituent on bioactivity.
Keywords: Coumarins, antibacterial, antifungal, β-amino alcohol coumarins, log P.
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