Beta-adrenergic blockers remain one of the cornerstones in the management of coronary artery disease,
both in chronic stable angina and myocardial infarction. These recommendations were based on studies
conducted in the era prior to the establishment of the modern therapy for ischemic heart disease and myocardial
infarction i.e. anti-platelet therapy, statins, and percutaneous coronary interventions. Recent studies emerged questioning
the beneficial effect of beta-blockers in the management of patients with stable ischemic heart disease and myocardial
infarction. In this review, we will discuss briefly the pharmacology of beta-blockers along the evidence that supports
the use of beta-blockers in the management of stable ischemic heart disease and myocardial infarction. The recent
studies questioning its use will also be discussed.
Keywords: Acute coronary syndrome, beta-blockers, mortality, myocardial infarction, stable angina.
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