Abstract
Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. In this minireview we have first analysed the RTK transactivation mechanisms, involving cholinergic receptors, and thereafter the interplay between AChR and neurotrophic factor systems built up by FGF2 and fibroblast growth factor receptor 1 (FGFR1). Although mAChR and FGFR1 activate common signaling pathways, playing similar roles in the regulation of central nervous system (CNS) plasticity and trophism, this analysis revealed that at the present there are no data reporting an involvement of cholinergic receptors in the FGFR1 transactivation. However, here we reported preliminary results on FGFR1 transactivation by mAChRs, suggesting a possible interaction between mAChR and neurotrophic factor receptors, with potential relevance for cognitive functions.
Keywords: FGFR1, G protein coupled receptor, Muscarinic receptors, Nicotinic receptors, Receptor-receptor interaction, Synaptic plasticity, Transactivation, Tyrosine-kinase receptors.
Current Protein & Peptide Science
Title:Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity
Volume: 15 Issue: 7
Author(s): Valentina Di Liberto, Giuseppa Mudo, Kjell Fuxe and Natale Belluardo
Affiliation:
Keywords: FGFR1, G protein coupled receptor, Muscarinic receptors, Nicotinic receptors, Receptor-receptor interaction, Synaptic plasticity, Transactivation, Tyrosine-kinase receptors.
Abstract: Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. In this minireview we have first analysed the RTK transactivation mechanisms, involving cholinergic receptors, and thereafter the interplay between AChR and neurotrophic factor systems built up by FGF2 and fibroblast growth factor receptor 1 (FGFR1). Although mAChR and FGFR1 activate common signaling pathways, playing similar roles in the regulation of central nervous system (CNS) plasticity and trophism, this analysis revealed that at the present there are no data reporting an involvement of cholinergic receptors in the FGFR1 transactivation. However, here we reported preliminary results on FGFR1 transactivation by mAChRs, suggesting a possible interaction between mAChR and neurotrophic factor receptors, with potential relevance for cognitive functions.
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Cite this article as:
Liberto Di Valentina, Mudo Giuseppa, Fuxe Kjell and Belluardo Natale, Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity, Current Protein & Peptide Science 2014; 15 (7) . https://dx.doi.org/10.2174/1389203715666140901112245
DOI https://dx.doi.org/10.2174/1389203715666140901112245 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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