Galanin Receptor/Neuropeptide Y Receptor Interactions in the Central Nervous System

Author(s): Zaida Diaz-Cabiale, Antonio Flores-Burgess, Concepcion Parrado, Manuel Narvaez, Carmelo Millon, Araceli Puigcerver, Rafael Covenas, Kjell Fuxe, Jose A. Narvaez

Journal Name: Current Protein & Peptide Science

Volume 15 , Issue 7 , 2014

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The presence of Galanin and Neuropeptide Y and/or their receptors in several areas of the brain involved in memory, mood, cardiovascular control and food intake indicates that Galanin, and Neuropeptide Y could equilibrate the physiological actions of each other. There is evidence for the existence of interactions between Galanin Receptor and Neuropeptide Y Receptor in the nucleus of the solitarii tract (NTS), hypothalamus and dorsal raphe nucleus probably taking place with the formation of heteromers between Galanin Receptor and Neuropeptide Y Y1 Receptor. The galanin fragment (Gal 1-15) preferring receptors may instead be formed by the GalR1-GalR2 heteromer which in the NTS may interact with Neuropeptide Y Y2 receptors. These receptor heteromers may be one key molecular mechanism for Galanin and its N-terminal fragment (Galanin 1-15) to modulate the function of different types of glia–neuronal networks in the CNS, especially the emotional, metabolic and cardiovascular networks.

Keywords: Galanin, Galanin 1-15, Galanin receptor subtypes, GPCRs, Heteromers, Neuropeptide Y, NPY receptors.

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Article Details

Year: 2014
Published on: 16 September, 2014
Page: [666 - 672]
Pages: 7
DOI: 10.2174/1389203715666140901111709
Price: $65

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