Abstract
We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular vein (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck. Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic (ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow duration and its onset from systole. We tested if these variables were statistically different among different MS phenotypes and between ST and NST MS patients. The delay between the beginning of systole and the CSF outflow was higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and CSF flow timing but not CSF flow amplitude.
Keywords: Cerebrospinal fluid, multiple sclerosis, phase contrast mri, venous stenosis.
Current Neurovascular Research
Title:Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging
Volume: 11 Issue: 4
Author(s): Maria Marcella Lagana, Anamika Chaudhary, Deepa Balagurunathan, David Utriainen, Paul Kokeny, Wei Feng, Pietro Cecconi, David Hubbard and E. Mark Haacke
Affiliation:
Keywords: Cerebrospinal fluid, multiple sclerosis, phase contrast mri, venous stenosis.
Abstract: We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular vein (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck. Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic (ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow duration and its onset from systole. We tested if these variables were statistically different among different MS phenotypes and between ST and NST MS patients. The delay between the beginning of systole and the CSF outflow was higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and CSF flow timing but not CSF flow amplitude.
Export Options
About this article
Cite this article as:
Lagana Marcella Maria, Chaudhary Anamika, Balagurunathan Deepa, Utriainen David, Kokeny Paul, Feng Wei, Cecconi Pietro, Hubbard David and Haacke Mark E., Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging, Current Neurovascular Research 2014; 11 (4) . https://dx.doi.org/10.2174/1567202611666140829161410
DOI https://dx.doi.org/10.2174/1567202611666140829161410 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bedside Lung Ultrasound in the Care of the Critically Ill
Current Respiratory Medicine Reviews Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry: An Attractive and Prospective Method for Quantitative Bioanalysis in Drug Metabolism
Current Drug Metabolism Extracellular Proteases as Targets for Drug Development
Current Protein & Peptide Science Impact of Mast Cell Chymase on Renal Disease Progression
Current Hypertension Reviews Coagulation Disorders in Acute Lung Injury
Current Respiratory Medicine Reviews Bevacizumab in Non Small Cell Lung Cancer: Development, Current Status and Issues
Current Medicinal Chemistry Gymnema sylvestre R. Br., an Indian Medicinal Herb: Traditional Uses, Chemical Composition, and Biological Activity
Current Pharmaceutical Biotechnology Respiratory Tract Manifestations of Rheumatic Diseases in Children
Current Respiratory Medicine Reviews Adult Stem Cell Therapy for Acute Brain Injury in Children
CNS & Neurological Disorders - Drug Targets Chemoprevention of Lung Pathologies by Dietary n-3 Polyunsaturated Fatty Acids
Current Medicinal Chemistry Current Management and Treatment of Cerebral Vasospasm Complicating SAH
CNS & Neurological Disorders - Drug Targets The Role of Diabetes Mellitus in Sexual and Reproductive Health: An Overview of Pathogenesis, Evaluation, and Management
Current Diabetes Reviews Novel Strategies for the Detection of Systolic and Diastolic Heart Failure
Current Cardiology Reviews From Brain Ischemia-Reperfusion Injury to Possible Sporadic Alzheimers Disease
Current Neurovascular Research Matrix Metalloproteinases as Potential Targets in the Venous Dilation Associated with Varicose Veins
Current Drug Targets Glucose Metabolism and Antidepressant Medication
Current Pharmaceutical Design Dopamine Administration in Very Low Birth Weight Preterm Infants:Emerging Issues on Endocrine Effects
Current Pediatric Reviews Pathophysiological Basis for Anticoagulant and Antithrombotic Therapy in Pulmonary Hypertension
Cardiovascular & Hematological Agents in Medicinal Chemistry Antifungal Prophylaxis in the Preterm Infant
Current Pediatric Reviews Dry Eye Disease: Present Challenges in the Management and Future Trends
Current Pharmaceutical Design