Anti-Metastatics: An Overview of Drug Candidates in Current Pipelines

Author(s): Anne Schaap-Nutt, Dane A. Thyssen, David W. Drell, Frank Entschladen

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 42 , 2014

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Abstract:

As the number of novel drugs that have entered the market in oncology has slowed in recent years, there has been a dramatic shift towards new therapeutic approaches. The majority of cancer patients die from metastasis formation, which has prompted the pharmaceutical industry to begin to investigate a new class of agents: anti-metastatics. This review provides an overview of the targets, mechanisms of action, and drug substances currently in the pharma pipeline to inhibit tumor cell migration and metastasis formation.

Keywords: Metastasis, invasion, cell migration, signal transduction.

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Article Details

VOLUME: 20
ISSUE: 42
Year: 2014
Page: [6522 - 6528]
Pages: 7
DOI: 10.2174/1381612820666140826152610
Price: $65

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