Abstract
Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.
Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.
Current Signal Transduction Therapy
Title:A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche
Volume: 9 Issue: 1
Author(s): Jialin Liu, Zhiwen Zhang, Jinghui Xue, Haitao Zhang, Yuxiao Liu and Fengyun Hu
Affiliation:
Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.
Abstract: Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.
Export Options
About this article
Cite this article as:
Liu Jialin, Zhang Zhiwen, Xue Jinghui, Zhang Haitao, Liu Yuxiao and Hu Fengyun, A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche, Current Signal Transduction Therapy 2014; 9 (1) . https://dx.doi.org/10.2174/1574362409666140820225940
DOI https://dx.doi.org/10.2174/1574362409666140820225940 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot Topic: Recent Perspectives on Nanoneuroprotection & Nanoneurotoxicity (Guest Editors: Hari Shanker Sharma and Aruna Sharma)]
CNS & Neurological Disorders - Drug Targets The Effect of a Four-Week Balance Training Program on Anticipatory Postural Adjustments in Older Adults: A Pilot Feasibility Study
Current Aging Science IAPs, their Antagonists and their Role in Neurological Disease and Cancer
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Guanylate Cyclase C: A Current Hot Target, from Physiology to Pathology
Current Medicinal Chemistry New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain
Current Drug Targets Perspectives of Medieval Persian Medicine on Multiple Sclerosis
Current Drug Metabolism Delivery Systems of Opioid Analgesics for Pain Relief: A Review
Current Pharmaceutical Design Nanotechnology and Antioxidant Therapy: An Emerging Approach for Neurodegenerative Diseases
Current Medicinal Chemistry Role of Mechanoinsensitive Nociceptors in Painful Diabetic Peripheral Neuropathy
Current Diabetes Reviews Exploring the Mechanism of Lingzhu San in Treating Febrile Seizures by Using Network Pharmacology
Combinatorial Chemistry & High Throughput Screening The Multiple Aspects of Stroke and Stem Cell Therapy
Current Molecular Medicine Bioactive Molecule-loaded Drug Delivery Systems to Optimize Bone Tissue Repair
Current Protein & Peptide Science Therapeutic Effects of Renal Denervation on Renal Failure
Current Neurovascular Research Inflammation in Neurodegenerative Disorders: Friend or Foe?
Current Aging Science Regulation of Ingestive Behavior, the Upper Gastrointestinal Motility and Gastric Acid Secretion by Ghrelin in Mammals
Current Nutrition & Food Science Neuroprotective Effects of Tetracyclines: Molecular Targets, Animal Models and Human Disease
CNS & Neurological Disorders - Drug Targets P2Y Receptors: Focus on Structural, Pharmacological and Functional Aspects in the Brain
Current Medicinal Chemistry Crosstalk Between Calpain and Calcineurin in Excitotoxic Neurodegeneration; Therapeutic Targets for the Treatment of Excitotoxic Neurodegeneration
Current Medicinal Chemistry - Central Nervous System Agents Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Calcium Channel α2δ Subunits: Structure, Functions and Target Site for Drugs
Current Neuropharmacology