Xanthomicrol: A Comprehensive Review of Its Chemistry, Distribution, Biosynthesis and Pharmacological Activity

Author(s): Mohammad Fattahi, Rosa M. Cusido, Abbas Khojasteh, Mercedes Bonfill, Javier Palazon

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 14 , Issue 9 , 2014

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Highly methoxylated flavones, which have known potential as cancer chemopreventive agents, accumulate on the leaf surfaces of some plant species and their physiological role is to protect the plant against harmful UV radiation. Xanthomicrol is one of the methoxylated flavones currently attracting most attention from researchers worldwide because of its promising pharmacological activities, including anti-spasmodic, anti-platelet and anti-cancer effects, among others. This review covers the chemistry and biological origin, distribution and pharmacological activity of xanthomicrol. Knowledge of the botanical distribution of this compound will not only encourage the use of plant sources for pharmacological purposes, but will also serve as a reference in the search for this valuable flavonoid in another genus or family. New approaches to xanthomicrol production are also described, including biotechnological attempts to develop xanthomicrol-producing plant cell factories.

Keywords: Cancer prevention, polyphenol bioavailability, Lamiaceae, methoxylated flavones, pharmacological activity, xanthomicrol.

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Article Details

Year: 2014
Published on: 23 September, 2014
Page: [725 - 733]
Pages: 9
DOI: 10.2174/1389557514666140820122818
Price: $65

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