Abstract
The emergence of drug resistant strains of important human pathogens has created an urgent necessity to find new targets and novel antitubercular agents. According to the literature survey, we noticed that enoyl ACP reductase is one of the most promising targets. This enzyme is the most important catalyst for the FAS II synthesis of mycolic acid, which is the most essential component of the mycobacterial cell wall. This review summarizes the progress made in the design of enoyl ACP reductase inhibitors and the role played by 3D-structure of the enzyme in drug design process.
Keywords: Drug design, Enoyl ACP reductase, Enoyl ACP reductase inhibitors, FAS-II.
Mini-Reviews in Medicinal Chemistry
Title:Enoyl ACP Reductase as Effective Target for the Synthesized Novel Antitubercular Drugs: A-State-of-the-Art
Volume: 14 Issue: 8
Author(s): Shrinivas D. Joshi, Sheshagiri R. Dixit, Uttam A. More, Tejraj M. Aminabhavi, Venkatrao H. Kulkarni and Andanappa K. Gadad
Affiliation:
Keywords: Drug design, Enoyl ACP reductase, Enoyl ACP reductase inhibitors, FAS-II.
Abstract: The emergence of drug resistant strains of important human pathogens has created an urgent necessity to find new targets and novel antitubercular agents. According to the literature survey, we noticed that enoyl ACP reductase is one of the most promising targets. This enzyme is the most important catalyst for the FAS II synthesis of mycolic acid, which is the most essential component of the mycobacterial cell wall. This review summarizes the progress made in the design of enoyl ACP reductase inhibitors and the role played by 3D-structure of the enzyme in drug design process.
Export Options
About this article
Cite this article as:
Joshi D. Shrinivas, Dixit R. Sheshagiri, More A. Uttam, Aminabhavi M. Tejraj, Kulkarni H. Venkatrao and Gadad K. Andanappa, Enoyl ACP Reductase as Effective Target for the Synthesized Novel Antitubercular Drugs: A-State-of-the-Art, Mini-Reviews in Medicinal Chemistry 2014; 14 (8) . https://dx.doi.org/10.2174/1389557514666140820112524
DOI https://dx.doi.org/10.2174/1389557514666140820112524 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Strategies for Developing Tuberculosis Vaccines: Emerging Approaches
Current Drug Targets Aging in Bacteria, Immortality or Not-A Critical Review
Current Aging Science Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research
Current Medicinal Chemistry Current Strategies in TB Immunotherapy
Current Molecular Medicine The Role of Coagulation and Fibrinolysis in the Pathogenesis of Acute Lung Injury
Current Respiratory Medicine Reviews Phenothiazines as Anti-Multi-Drug Resistant Tubercular Agents
Infectious Disorders - Drug Targets Human Anthrax as a Re-Emerging Disease
Recent Patents on Anti-Infective Drug Discovery Recursive Partitioning Analysis and Anti-Tubercular Screening of 3- Aminopyrazine-2-Carbohydrazide Derivatives
Letters in Drug Design & Discovery Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
Current Microwave Chemistry Similarities/Dissimilarities Analysis of Protein Sequences Based on Recurrence Quantification Analysis
Current Bioinformatics Patent Selections:
Recent Patents on Drug Delivery & Formulation Radiopharmaceutical: Revolutionary Agents for Diagnosis
Current Radiopharmaceuticals Type 2 Diabetes and its Impact on the Immune System
Current Diabetes Reviews Fungal Zinc Homeostasis – A Tug of War Between the Pathogen and Host
Current Medicinal Chemistry Adherence to Anti-Retroviral Therapy in North Central Nigeria
Current HIV Research Tuberculosis, an Old Disease Lacking New Therapeutic Drugs
Current Drug Therapy Cycloxygenase-2 (COX-2) - A Potential Target for Screening of Small Molecules as Radiation Countermeasure Agents: An In Silico Study
Current Computer-Aided Drug Design Angiogenin as a Molecular Target for the Treatment of Prostate Cancer
Current Cancer Therapy Reviews Diagnosis and Therapeutic Approaches to Transthyretin Amyloidosis
Current Medicinal Chemistry Dibenzofurans from Lichens – A Pharmacological Overview
Current Topics in Medicinal Chemistry