As important members of the terpenes family, sesquiterpenes represent a group of natural compounds with
diverse skeletal types. Among them, the eremophilane-type sesquiterpenes, widely present in several genera (such as
Ligularia, Senecio, Cacalia) of Asteraceae, account for a small number of natural compounds and form differently from
other sesquiterpenes because they challenged the isoprene rule of biosynthesis. Due to the unique structural features and
various functional groups, these compounds possess a number of biological activities such as anti-tumor, anti-bacterial
and anti-inflammatory, having received increasing interest in the recent years. This review summarizes the occurrence of
eremophilane-type sesquiterpenes and research progresses on their biological activities since the 1990s.
Keywords: Anti-tumor, anti-microbial, anti-inflammatory, anti-allergy, eremophilane-type sesquiterpenes.
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