Analysis of Genome-scale Expression Network in Four Major Bacterial Residents of Cystic Fibrosis Lung

Author(s): Nazanin Hosseinkhan, Peyman Zarrineh, Ali Masoudi-Nejad

Journal Name: Current Genomics

Volume 15 , Issue 5 , 2014

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Graphical Abstract:


In polymicrobial communities where several species co-exist in a certain niche and consequently the possibility of interactions among species is very high, gene expression data sources can give better insights in to underlying adaptation mechanisms assumed by bacteria. Furthermore, several possible synergistic or antagonistic interactions among species can be investigated through gene expression comparisons. Lung is one of the habitats harboring several distinct pathogens during severe pulmonary disorders such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Expression data analysis of these lung residents can help to gain a better understanding on how these species interact with each other within the host cells. The first part of this paper deals with introducing available data sources for the major bacteria responsible for causing lung diseases and their genomic relations. In the second part, the main focus is on the studies concerning gene expression analyses of these species.

Keywords: Lung resident organisms, Differentially expressed genes, Cystic fibrosis.

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Article Details

Year: 2014
Published on: 06 November, 2014
Page: [408 - 418]
Pages: 11
DOI: 10.2174/1389202915666140818205444
Price: $65

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