Title:Inhibition of Candida rugosa Lipase by Different Extracts of Five Algerian Plants and their Antioxidant Activities
VOLUME: 10 ISSUE: 2
Author(s):Madjda Benguechoua, Samira Nia, Khedidja Benarous, Ihcen Khachba and Mohammed Yousfi
Affiliation:Universite Amar Telidji, Laghouat-Algerie.
Keywords:Antioxidant activities, Candida rugosa lipase inhibition, Echium vulgare L, Marrubium vulgare L, Thymus
algeriensis, Thymus sepyllum, Zygophyllum album.
Abstract:Lipase inhibitors are drugs used to reduce the activity of lipase found in the intestine. These inhibitors are used
for the treatment of obesity and cardiovascular diseases. The purpose of this work was to explore in vitro the enzymatic
and antioxidant activities of secondary metabolites extracts such as, phenolic compounds, flavonoids and tannins obtained
with various extraction solvent systems: methanol/water, acetone/water and methanol/acetone/water from the aerial parts
of five medicinal Algerian plants: Thymus algeriensis, Zygophyllum album, Thymus sepyllum, Marrubium vulgare L and
Echium vulgare L. The lipase inhibition by these extracts described here has been for the first time. The results have
shown a potent inhibitor, activity of lipase in acetone/water extraction mixture with ethyl acetate and butanol fractions
from Thymus sepyllum and in methanol/acetone/water extraction mixture with ethyl acetate fraction from Marrubium vulgare
L. The evaluation of antioxidant capacity was achieved by three chemical tests DPPH, Phosphomolybdenum and
ABTS showing that our extracts possess potential antioxidant activities compared to standards.
