In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is
fast becoming an alternative to other existing strategies of drug development. These hybrids also known as ‘dual drugs’ or
‘double drugs’ are especially found to be effective in overcoming drug resistance problems. Towards this end, a lot of effort
has been put for generating 4-aminoquinoline based hybrid molecules as next generation antimalarial drugs effective
in malarial chemotherapy. This short review deals about the recent advances carried in the field of 4-aminoquinoline
based molecular hybrids as potential antimalarial agents. It also presents a brief and simplified story on the development
of 4-aminoquinolines as a mainstay in malarial research programmes.
Keywords: 4-Aminoquinoline, antimalarial, artemisinin, hybrid, pfDHFR.
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