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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Ferroquine as an Oxidative Shock Antimalarial

Author(s): Daniel Dive and Christophe Biot

Volume 14, Issue 14, 2014

Page: [1684 - 1692] Pages: 9

DOI: 10.2174/1568026614666140808122329

Price: $65

Abstract

Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.

Keywords: Malaria, ferroquine, mechanism of action, hydrogen bond, redox behavior.

Graphical Abstract

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