Antimalarial Activities of Indolones and Derivatives

Author(s): Francoise Nepveu, Ennaji Najahi, Alexis Valentin

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 14 , 2014

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Graphical Abstract:


The search for antimalarial compounds continues to be an area of intensive investigation in medicinal chemistry. This review presents the structural variations around the indolone-N-oxide core. From these pharmacomodulation studies, new antiplasmodial agents with various structures have emerged. Most of the molecules generated from reduced forms of the indolone scaffold have led to compounds with antiplasmodial properties. These results confirm the importance of the redox reversibility of the bioreducible N=C bond in these series to obtain antimalarial activities.

Keywords: Antimalarials, hit identification, indolones, indolone-N-oxides, Plasmodium falciparum.

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Article Details

Year: 2014
Page: [1643 - 1652]
Pages: 10
DOI: 10.2174/1568026614666140808121329
Price: $65

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