Toll-Like Receptors in Alzheimer's Disease: A Therapeutic Perspective

Author(s): Maria E. Gambuzza, Vincenza Sofo, Francesca M. Salmeri, Luca Soraci, Silvia Marino, Placido Bramanti

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 13 , Issue 9 , 2014

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Alzheimer’s disease (AD) is a neurodegenerative disorder mainly characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic neuroinflammation. Emerging data highlight the involvement of innate immunity, that has been shown to play opposing roles during the AD progression. Activated microglia and reactive astrocytes exert neuroprotection mediated through Aβphagocytosis in the early stage, whereas, as the disease progresses, they fail in Aβclearance and exert detrimental effects, including neuroinflammation and neurodegeneration. Specific toll-like receptors (TLRs) and coreceptors can directly or indirectly be activated to induce Aβ uptake or inflammatory responses, depending on the disease stage. Fibrillar Aβcan directly interact with TLR2, TLR4, and CD14 to induce microglial Aβphagocytosis in the beginning stages, and neuroinflammatory responses in the late stages. Early TLR3-mediated signal enhances neuronal Aβautophagy, although it increases neuronal apoptosis in the late AD stage. Similarly, TLR7, TLR8 and TLR9 can enhance microglial Aβuptake in the early stage, but over time they contribute to neuroinflammation. Therefore, TLRs, and in particular TLR2 and TLR4, represent a suitable target for therapeutic intervention within the disease progression and targeting them carefully could increase Aβ autophagy and phagocytosis or reduce inflammatory responses. Several modulators with selective TLR agonist or antagonist activity have been developed, and many of them could have a therapeutic benefit in AD patients. This paper outlines the role of specific TLRs in AD, also focusing on TLR-targeted compounds yet indicated for the treatment of other inflammatory diseases, that could be used to treat the different stages of the disease.

Keywords: Alzheimer’s disease, amyloid-beta, autophagy, inflammation, phagocytosis, Toll-like receptors, Toll-like receptortargeted therapeutics.

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Article Details

Year: 2014
Published on: 12 December, 2014
Page: [1542 - 1558]
Pages: 17
DOI: 10.2174/1871527313666140806124850
Price: $65

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