The human cathelicidin-18 is an antimicrobial, immunomodulatory and tissue repair peptide. The LL-37 fragment
of this peptide which is in fact the active domain of the cathelicidin-18 is critical for the human antibacterial defense
and epithelial integrity. It's activity against resistant pathogens, the potential of epithelial healing after microbial injury
and the neutralization of bacterial endotoxin underlie the most important benefits of this peptide. However, there are still a
number of questions that remain to be answered regarding the precise interactions of cathelicidin-18 within the immune
system, the exact tissue concentrations or its possible pro-tumoral activity. In this respect, the therapeutic potential of
cathelicidin-18 in various infections has been proved by in vitro experiments, but additional detailed clinical studies are
still required to ascertain its antimicrobial role in vivo.
We present a short review on the antibacterial activity of human cathelicidin-18 (LL-37) according to in vitro experiments
while discussing its potential use in the clinical practice.
Keywords: Antibacterial activity, antimicrobial peptides, bacterial infections, cathelicidin-18, immunomodulatory activity, LL-
Rights & PermissionsPrintExport