Title:Polymeric Nanocarriers for the Oral Delivery of Bioactives
VOLUME: 9 ISSUE: 1
Author(s):Rajeev Sharma, Udita Agrawal and Suresh P. Vyas
Affiliation:Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Viswavidyalaya, Sagar-470003 M.P, India.
Keywords:Caco-2 cell monolayers, dendrimers, nanoparticles, oral delivery.
Abstract:The oral delivery of therapeutics is of paramount importance to medical application and advancement. There
has been remarkable advancement in the field of polymeric formulations for oral delivery of therapeutics. Novel
polymeric formulation like polymeric nanoparticles, micelles and dendrimers are exploited and researched to further
improve the bioavailability, stability, permeability and therapeutic efficacy. Over the last years, there have been number of
approaches used for the effective delivery of bioactive(s). These include chemical modification, use of enzyme inhibitors
and permeation enhancers, and novel drug delivery systems. Numerous polymeric nanoarchitectures based strategies are
able to overcome restrictions and show the promising approach for efficient [P/P] drugs oral delivery. The aim of present
review focuses on the need for the development of polymeric nanocarrier for oral-peptide and protein delivery with
emphases on insulin delivery via various polymeric nanocarriers.
