Apoptosis induction provides a promising strategy for tumor gene therapy. Non-invasive ultrasound
is a novel non-virus transfer method. In the field of cancer therapy, it has been found that ultrasound alone or
together with microbubble represents an appealing, efficient and novel technique, which could deliver
therapeutic gene or drug to specific organs or tissues in a simple and noninvasive way. Moreover, apoptosis
induction mediated by the novel ultrasound-targeted microbubble destruction technique is safer and more
effective than other methods, inactivating tumor cells, restraining cell proliferation and improving therapeutic
effects of gene or chemotherapeutic drugs. In this paper, we reviewed apoptosis induction by ultrasound and
microbubble mediated drug delivery and gene therapy in vitro and in vivo.
Keywords: Apoptosis, cancer, drug delivery, gene transfer, microbubble, sonoporation, therapy, ultrasound.
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