Abstract
A series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when compared to standard drugs.
Keywords: 2-substituted benzimidazole, antibacterial activity, antifungal activity, ethyl-piperidine-4-carboxylic acid, hybrid molecules, pyridine.
Letters in Drug Design & Discovery
Title:Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents
Volume: 12 Issue: 1
Author(s): Kothapally. Beulah, Akula Ravi Kumara, Boddupally Peda Venkat Lingaiah, Pamulaparthy Shanthan Rao, Banda Narsaiah, Aaramadaka Sunil Kumar Reddy and Upadhyayula Surya Narayana Murty
Affiliation:
Keywords: 2-substituted benzimidazole, antibacterial activity, antifungal activity, ethyl-piperidine-4-carboxylic acid, hybrid molecules, pyridine.
Abstract: A series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when compared to standard drugs.
Export Options
About this article
Cite this article as:
Beulah Kothapally., Kumara Ravi Akula, Lingaiah Peda Venkat Boddupally, Rao Shanthan Pamulaparthy, Narsaiah Banda, Reddy Sunil Kumar Aaramadaka and Murty Surya Narayana Upadhyayula, Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents, Letters in Drug Design & Discovery 2015; 12 (1) . https://dx.doi.org/10.2174/1570180811666140725185713
DOI https://dx.doi.org/10.2174/1570180811666140725185713 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pathophysiology of Transmissible Spongiform Encephalopathies
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Stem Cells: In Sickness and in Health
Current Stem Cell Research & Therapy The Potential Clinical Properties of Magnesium
Current Medicinal Chemistry Manipulation of Intracellular pH in Cancer Cells by NHE1 Inhibitors
Protein & Peptide Letters MG17, A Novel Triazole Derivative Abrogated Neuroinflammation and Related Neurodegenerative Symptoms in Rodents
Current Molecular Pharmacology Determination of Phytochemicals by GC-MS in Two Fractions (17 and 21) of Methanol Extract of Loranthus Micranthus and their Antioxidant and Anti-Inflammatory Activity
The Natural Products Journal The Patch Clamp Technique in Ion Channel Research
Current Pharmaceutical Biotechnology Therapeutic Management of COVID-19 Patients: Clinical Manifestation and Limitations
Current Pharmaceutical Design Cyclooxygenases in the Central Nervous System: Implications for Treatment of Neurological Disorders
Current Pharmaceutical Design Sao Paulo Research Conference on Molecular Medicine and Pharmacogenetics, A Joint Meeting with the IUPHAR Sub-Committee on Pharmacogenetics and the Brazilian Pharmacogenetics Network, Sao Paulo, Brazil, September 18-20, 2008
Current Pharmacogenomics and Personalized Medicine HTLV-1 Associated Neurological Disorders
Current Topics in Medicinal Chemistry Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging
Current Medicinal Chemistry Neurotransmitter Effects in Human Immunodeficiency Virus (HIV) and Simian Immuno-Deficiency Virus (SIV) Infection
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Histone Acetylation in Neurodevelopment
Current Pharmaceutical Design Raf Inhibitors as Therapeutic Agents Against Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Meet the Editorial Board
CNS & Neurological Disorders - Drug Targets Cooling the Injured Brain: How Does Moderate Hypothermia Influence the Pathophysiology of Traumatic Brain Injury
Current Pharmaceutical Design Suicidality and Cannabidiol: Opportunities and Challenges
Current Neuropharmacology The GABAA-BZR Complex as Target for the Development of Anxiolytic Drugs
Current Topics in Medicinal Chemistry Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets