A series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized
by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity
against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative
organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains
like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI
Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when
compared to standard drugs.