Tannins and their Influence on Health
Pp. 159-208 (50)
Kateřina Macáková, Vít Kolečkář, Lucie Cahlíková, Jakub Chlebek, Anna Hošťálková, Kamil Kuča, Daniel Jun and Lubomír Opletal
Natural polyphenols are a wide class of secondary plant metabolites and
represent an abundant antioxidant component of human diet. An important, but often
neglected, group of natural polyphenols are tannins. This review offers a general
description of chemistry of hydrolysable and condensed tannins (proanthocyanidins),
and phlorotannins, the mechanisms of their antioxidation action, like free radical
scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes
and lipid peroxidation. The mechanisms of action of inhibition of various enzyme
systems, antibacterial, antiviral, antiprotozoal, anticarcinogenic, antidiabetic,
hepatoprotective, cardiovascular system preventing, immunomodulation, antiallergic
and anti-inflammatory effects as well as the absorption, metabolic fate and positive in
vivo effects of tannins are enclosed.
Adverse effects, biological activity, metabolism, phlorotannins,
Department of Pharmaceutical Botany and Ecology, ADINACO Research Group, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.