Recent Advances in Medicinal Chemistry

Volume: 1

Indexed in: Book Citation Index, Science Edition; BIOSIS Previews, EBSCO.

Recent advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
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Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics

Pp. 131-158 (28)

Yunierkis Pérez-Castillo, Matheus Froeyen, Ann Nowé and Miguel Ángel Cabrera-Pérez


The emergence of drug resistant strains of important human pathogens has made urgent the necessity of finding new targets and novel antimicrobial agents. One of the most promising targets is FabH. Here we summarize the progress made in the design of FabH inhibitors and the role played by the 3D-structure of the enzyme as well as by the modeling studies in the design of new FabH inhibitors.


Drug design, FabH, FAS, FabH inhibitors.


Molecular Simulation & Drug Design Group. Centro de BioactivosQuímicos. Universidad Central de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.