Characterization of Inorganic Nanomaterials as Therapeutic Vehicles
Pp. 73-98 (26)
Tatsuya Murakami, Masako Yudasaka, Sumio Iijima and Kunihiro Tsuchida
For effective drug actions, concentrations of drugs in the target tissues must
be sufficient enough with minimal levels of degradation and dilution. It is desirable that
drugs are delivered to the target tissues efficiently. It is also preferable that drugs and
therapeutic chemicals do not affect normal tissues. Various methods for drug delivery
systems to enhance drug efficacy and reduce adverse drug effects, have been devised by
the concomitant development of novel nanomaterials. Nanobiotechnology is one of
emerging scientific area that has utilized a variety of inorganic and organic
nanomaterials. Each inorganic nanomaterial has its own unique characteristics. In this
review, we focus on the usefulness of inorganic nanomaterials, including iron oxide
nanoparticles and gold nanoparticles. We also feature fullerenes and carbon nanohorns,
both of which are composed entirely of carbons, as therapeutic vehicles, and summarize
recent advances in this exciting field of nanoscience and its medical applications.
Nanomedicine, drug delivery, iron oxide nanoparticle, gold
nanoparticle, fullerene, carbon nanohorn.
Division for Therapies against Intractable Diseases Institute for Comprehensive Medical Sciences (ICMS) Fujita Health University Toyoake, Aichi 470-1192, Japan.