Pioneer works have identified some microRNAs (miRNAs) with oncogenic or tumor-suppressive properties in
glioblastoma multiforme (GBM), an aggressive brain tumor with dismal prognosis. Differential expression of these noncoding
small RNA in cancers positions them as attractive biomarkers for diagnosis, prognosis and therapeutic decision in
GBMs. In addition, abnormal miRNAs provide new interesting therapeutic targets for clinical GBM treatments despite the
hurdles associated with such an approach. This review firstly summarizes abnormal expressed genes and upstream
miRNAs in GBMs. Next, our focus will be towards the signature of miRNAs in GBM, and discuss the importance of
circulating miRNAs for cancer diagnosis. Finally, we summarize present miRNA target therapeutic strategies, and discuss
the deficiencies and challenges.