Abstract
Contrast induced nephropathy (CIN) is an iatrogenic form of acute kidney injury (AKI) with variable but growing prevalence secondary to increased need for contrast administration during medical investigations such as coronary angiography. The mechanism of CIN is complex and poorly understood but is believed to be secondary to renal medullary hypoxia secondary to direct tubular toxicity from the contrast media and vasoconstriction. N-acetylcysteine (NAC) an antioxidant and vasodilator, has shown promising results in early investigations but failed to demonstrate consistent results in subsequent clinical trials and their meta-analysis. In this review we aim to discuss pharmacological properties of NAC and appraise the literature regarding the use of NAC for the prevention of CIN after coronary angiography.
Keywords: Acetylcysteine/therapeutic use, angiography/adverse effects, contrast media/adverse effects, humans, kidney diseases/chemically induced, kidney diseases/prevention & control.
Current Drug Therapy
Title:Use of N-acetyl-cysteine to Prevent Nephrotoxicity Associated with Iodinated Contrast Agents
Volume: 9 Issue: 2
Author(s): Mayank K. Mittal, Kanupriya Jain, Harsh Agrawal, Poonam Velagapudi, Sonal Dhuper and Arun Kumar
Affiliation:
Keywords: Acetylcysteine/therapeutic use, angiography/adverse effects, contrast media/adverse effects, humans, kidney diseases/chemically induced, kidney diseases/prevention & control.
Abstract: Contrast induced nephropathy (CIN) is an iatrogenic form of acute kidney injury (AKI) with variable but growing prevalence secondary to increased need for contrast administration during medical investigations such as coronary angiography. The mechanism of CIN is complex and poorly understood but is believed to be secondary to renal medullary hypoxia secondary to direct tubular toxicity from the contrast media and vasoconstriction. N-acetylcysteine (NAC) an antioxidant and vasodilator, has shown promising results in early investigations but failed to demonstrate consistent results in subsequent clinical trials and their meta-analysis. In this review we aim to discuss pharmacological properties of NAC and appraise the literature regarding the use of NAC for the prevention of CIN after coronary angiography.
Export Options
About this article
Cite this article as:
K. Mittal Mayank, Jain Kanupriya, Agrawal Harsh, Velagapudi Poonam, Dhuper Sonal and Kumar Arun, Use of N-acetyl-cysteine to Prevent Nephrotoxicity Associated with Iodinated Contrast Agents, Current Drug Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574885509666140716171925
DOI https://dx.doi.org/10.2174/1574885509666140716171925 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Chemical Genetics Approach for Specific Differentiation of Stem Cells to Somatic Cells: A New Promising Therapeutical Approach
Combinatorial Chemistry & High Throughput Screening Biological Actions and Metabolism of Currently Used Pharmacological Agents for the Treatment of Congestive Heart Failure
Current Drug Metabolism Highest Mortality During the Last Year Before and the First Year After Start of Dialysis Treatment in Type 2 Diabetic Patients with Nephropathy
Current Diabetes Reviews Drug Combinations for Dyslipidemia and Obesity Treatment in Metabolic Syndrome
Current Pharmaceutical Design Role of Nitrosative Stress and Poly(ADP-ribose) Polymerase Activation in Diabetic Vascular Dysfunction
Current Vascular Pharmacology Perinatal Management of Fetal Tumors
Current Pediatric Reviews Epigenetics in Neurodegenerative Diseases: The Role of Histone Deacetylases
CNS & Neurological Disorders - Drug Targets Chloroplast Protein Import: Reverse Genetic Approaches
Current Genomics Topoisomerase Enzymes as Therapeutic Targets for Cancer Chemotherapy
Medicinal Chemistry Calcium Channels and Prostate Cancer
Recent Patents on Anti-Cancer Drug Discovery Mechanisms Involved in the Genesis of Diabetic Nephropathy
Current Diabetes Reviews Hypertriglyceridemia - Common Causes, Prevention and treatment Strategies
Current Cardiology Reviews Exploring Mechanisms of MicroRNA Downregulation in Cancer
MicroRNA Health-Care Associated Pneumonia (HCAP): Identification of Low and High-Risk Patients
Current Respiratory Medicine Reviews Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions
Current Protein & Peptide Science From Lizard to Snake; Behind the Evolution of an Extreme Body Plan
Current Genomics From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimer’s Disease
Current Neuropharmacology “Endothelial Progenitor Cells” as a Therapeutic Strategy in Cardiovascular Disease
Current Vascular Pharmacology Diabetes and Vascular Disease: Is It All About Glycemia?
Current Pharmaceutical Design Influence of a High-Fat Diet on Cardiac iNOS in Female Rats
Current Vascular Pharmacology