Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

Title:Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

VOLUME: 10 ISSUE: 3

Author(s):Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca and Antonio Fiorentino

Affiliation:Department of Environmental Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, I-81100, Caserta, Italy.

Keywords:Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.

Abstract:Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (¹H, ¹³C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).

Cite this article as:

Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca and Antonio Fiorentino, “Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex”, Current Bioactive Compounds (2014) 10: 196. https://doi.org/10.2174/1573407210666140716163923

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