Abstract
The chemical compositions of essential oils from cumin and coriander fruits were investigated using GLC and GLC/MS. Forty six compounds were identified in both oils. The major constituents of cumin oil were identified as γ- terpinene (22.7%), β-pinene (19.2%), cuminaldehyde (18.0%), p-cymene (11.5%), whereas linalool (70.43%) is the most abundant component in coriander oil. The antioxidant and anti-inflammatory activity and cytotoxicity of the essential oils were assessed. Cumin oil exhibited stronger antioxidant activity (IC50 values, 2.37 mg/ml for DPPH• assay and 27.7 μg/ml for OH• assay) as compared to the coriander oil. Both oils inhibited the PGE2 production in lipopolysaccharide (LPS) stimulated HepG-2 cells. They also inhibited soybean lipoxygenase (5-LOX). Cumin oil (20 μg/ml) caused a 22.44% reduction in PGE2 level after treatment of the cells. IC50 values for lipoxygenase inhibition were 35.8 and 38.6 μg/ml for cumin and coriander oils, respectively. Cumin oil exhibited substantial antiproliferative activity against HepG-2 with an IC50 value of 31.4 μg/ml, whereas coriander was less active (IC50 120.4 μg/ml).
Keywords: Anti-inflammatory activity, antioxidant, chemical composition, coriander, cumin, cytotoxicity, GLC, GLC/MS.
The Natural Products Journal
Title:Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt
Volume: 4 Issue: 1
Author(s): Rasha S. Hanafi, Mansour Sobeh, Mohamed L. Ashour, Mahmoud Z. El-Readi, Samar Y. Desoukey, Raimund Niess, Ashraf H. Abadi and Michael Wink
Affiliation:
Keywords: Anti-inflammatory activity, antioxidant, chemical composition, coriander, cumin, cytotoxicity, GLC, GLC/MS.
Abstract: The chemical compositions of essential oils from cumin and coriander fruits were investigated using GLC and GLC/MS. Forty six compounds were identified in both oils. The major constituents of cumin oil were identified as γ- terpinene (22.7%), β-pinene (19.2%), cuminaldehyde (18.0%), p-cymene (11.5%), whereas linalool (70.43%) is the most abundant component in coriander oil. The antioxidant and anti-inflammatory activity and cytotoxicity of the essential oils were assessed. Cumin oil exhibited stronger antioxidant activity (IC50 values, 2.37 mg/ml for DPPH• assay and 27.7 μg/ml for OH• assay) as compared to the coriander oil. Both oils inhibited the PGE2 production in lipopolysaccharide (LPS) stimulated HepG-2 cells. They also inhibited soybean lipoxygenase (5-LOX). Cumin oil (20 μg/ml) caused a 22.44% reduction in PGE2 level after treatment of the cells. IC50 values for lipoxygenase inhibition were 35.8 and 38.6 μg/ml for cumin and coriander oils, respectively. Cumin oil exhibited substantial antiproliferative activity against HepG-2 with an IC50 value of 31.4 μg/ml, whereas coriander was less active (IC50 120.4 μg/ml).
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S. Hanafi Rasha, Sobeh Mansour, L. Ashour Mohamed, Z. El-Readi Mahmoud, Y. Desoukey Samar, Niess Raimund, H. Abadi Ashraf and Wink Michael, Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt, The Natural Products Journal 2014; 4 (1) . https://dx.doi.org/10.2174/221031550401140715152051
DOI https://dx.doi.org/10.2174/221031550401140715152051 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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