Abstract
Re-investigation of the methanolic extract of the sponge Diacarnus megaspinorhabdosa afforded one new norsesterpene cyclic peroxide megaspinoxide A (2), together with two known compounds sigmosceptrellin B (1) and nebularine (3). The structures of the isolated compounds were established on the basis of one and two dimensional NMR spectroscopic studies (1H, 13C, DEPT, COSY, HMQC, HMBC, and ROESY) as well as, mass spectral analysis. The isolated compounds were evaluated for their cytotoxic and antimicrobial activities.
Keywords: Diacarnus megaspinorhabdosa, norsesterpene, megaspinoxide A, sigmosceptrellin B, nebularine, cytotoxic, antimicrobial.
The Natural Products Journal
Title:Megaspinoxide A: New Norterpene Cyclic Peroxide from the Sponge Diacarnus megaspinorhabdosa
Volume: 4 Issue: 1
Author(s): Sabrin R.M. Ibrahim, Rwaida A. Al Haidari and Gamal A. Mohamed
Affiliation:
Keywords: Diacarnus megaspinorhabdosa, norsesterpene, megaspinoxide A, sigmosceptrellin B, nebularine, cytotoxic, antimicrobial.
Abstract: Re-investigation of the methanolic extract of the sponge Diacarnus megaspinorhabdosa afforded one new norsesterpene cyclic peroxide megaspinoxide A (2), together with two known compounds sigmosceptrellin B (1) and nebularine (3). The structures of the isolated compounds were established on the basis of one and two dimensional NMR spectroscopic studies (1H, 13C, DEPT, COSY, HMQC, HMBC, and ROESY) as well as, mass spectral analysis. The isolated compounds were evaluated for their cytotoxic and antimicrobial activities.
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Cite this article as:
R.M. Ibrahim Sabrin, A. Al Haidari Rwaida and A. Mohamed Gamal, Megaspinoxide A: New Norterpene Cyclic Peroxide from the Sponge Diacarnus megaspinorhabdosa, The Natural Products Journal 2014; 4 (1) . https://dx.doi.org/10.2174/221031550401140715145414
DOI https://dx.doi.org/10.2174/221031550401140715145414 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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