Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins

Author(s): Darja Kanduc

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 14 , Issue 3 , 2014

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Abstract:

This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis–associated antigens and male fertility disorders.

Keywords: Infertility, mumps immunogenicity, peptide crossreactivity, spermatogenesis-associated proteins, sterility.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2014
Page: [218 - 225]
Pages: 8
DOI: 10.2174/1871530314666140715115257
Price: $65

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