Recent Advances in Molecular Biology of Parasitic Viruses

Author(s): Gouri Rani Banik, Damien Stark, Harunor Rashid, John T. Ellis

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 14 , Issue 3 , 2014

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The numerous protozoa that can inhabit the human gastro-intestinal tract are known, yet little is understood of the viruses which infect these protozoa. The discovery, morphologic details, purification methods of virus-like particles, genome and proteome of the parasitic viruses, Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and the Eimeria sp. are described in this review. The protozoan viruses share many common features: most of them are RNA or double-stranded RNA viruses, ranging between 5 and 8 kilobases, and are spherical or icosahedral in shape with an average diameter of 30-40 nm. These viruses may influence the function and pathogenicity of the protozoa which they infect, and may be important to investigate from a clinical perspective. The viruses may be used as specific genetic transfection vectors for the parasites and may represent a research tool. This review provides an overview on recent advances in the field of protozoan viruses.

Keywords: Cell biology, double-stranded RNA virus, parasite, parasitic virus, protozoa, protozoan virus.

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Article Details

Year: 2014
Page: [155 - 167]
Pages: 13
DOI: 10.2174/1871526514666140713160905
Price: $65

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PDF: 51