Abstract
Late life depression is a prevalent disorder that affects elderly population. However, it is frequently sub diagnosed due to great variability in the sample involved, the definition of depression, the methodology used, and the experience of the evaluator.
Different subtypes of geriatric depression exist, each one with its own clinical characteristics. Depressive symptoms often are accompanied by cognitive impairment. Various diagnostic studies must be done to evaluate late life depression, such as depression scales, neuropsychological test, laboratory analyses and Neuroimages. As regards to treatment, antidepressants are always the first line option, especially IRSS due to its effectiveness and low rates of adverse events. Antipsychotics may provide benefit for agitated, psychotic, or resistant MDD in the elderly. Mood stabilizers are useful in bipolar depression such as lamotrigine, lithium and divalproate. This review aims to define the different subtypes of geriatric depression, describe diagnostic methods and revise recent data about pharmacological treatment.
Keywords: Clinical manifestations, diagnosis, late life depression, treatment.
Current Psychopharmacology
Title:Late Life Depression: A Diagnostic and Pharmacological Review
Volume: 3
Author(s): Carol Dillon, Clara Rodriguez and Fernando E. Taragano
Affiliation:
Keywords: Clinical manifestations, diagnosis, late life depression, treatment.
Abstract: Late life depression is a prevalent disorder that affects elderly population. However, it is frequently sub diagnosed due to great variability in the sample involved, the definition of depression, the methodology used, and the experience of the evaluator.
Different subtypes of geriatric depression exist, each one with its own clinical characteristics. Depressive symptoms often are accompanied by cognitive impairment. Various diagnostic studies must be done to evaluate late life depression, such as depression scales, neuropsychological test, laboratory analyses and Neuroimages. As regards to treatment, antidepressants are always the first line option, especially IRSS due to its effectiveness and low rates of adverse events. Antipsychotics may provide benefit for agitated, psychotic, or resistant MDD in the elderly. Mood stabilizers are useful in bipolar depression such as lamotrigine, lithium and divalproate. This review aims to define the different subtypes of geriatric depression, describe diagnostic methods and revise recent data about pharmacological treatment.
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Cite this article as:
Dillon Carol, Rodriguez Clara and Taragano E. Fernando, Late Life Depression: A Diagnostic and Pharmacological Review, Current Psychopharmacology 2014; 3 (1) . https://dx.doi.org/10.2174/2211556003666140702185640
DOI https://dx.doi.org/10.2174/2211556003666140702185640 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
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Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
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