Abstract
Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.
Keywords: Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.
Current Molecular Pharmacology
Title:Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish
Volume: 7
Author(s): Guangxun Gao, Liang Chen and Chuanshu Huang
Affiliation:
Keywords: Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.
Abstract: Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.
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Cite this article as:
Gao Guangxun, Chen Liang and Huang Chuanshu, Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish, Current Molecular Pharmacology 2014; 7 (1) . https://dx.doi.org/10.2174/1874467207666140702113629
DOI https://dx.doi.org/10.2174/1874467207666140702113629 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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