Abstract
Herein, we report cellulose sulfuric acid (CSA) as a heterogeneous, eco-friendly, reusable catalyst for the synthesis of β -indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 °C for 1.5–4 h. The structures of the synthesized compounds were evaluated by spectral data. All the synthesized compounds were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal (C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity and antimicrobial activity of β-indolylketones.
Keywords: β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, michael addition.
Current Pharmaceutical Analysis
Title:Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity
Volume: 10 Issue: 4
Author(s): Y.L.N. Murthy, Praveen Choppara, Y.V. Prasad and T.J.U. Ranjan
Affiliation:
Keywords: β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, michael addition.
Abstract: Herein, we report cellulose sulfuric acid (CSA) as a heterogeneous, eco-friendly, reusable catalyst for the synthesis of β -indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 °C for 1.5–4 h. The structures of the synthesized compounds were evaluated by spectral data. All the synthesized compounds were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal (C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity and antimicrobial activity of β-indolylketones.
Export Options
About this article
Cite this article as:
Murthy Y.L.N., Choppara Praveen, Prasad Y.V. and Ranjan T.J.U., Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity, Current Pharmaceutical Analysis 2014; 10 (4) . https://dx.doi.org/10.2174/1573412910666140630165745
DOI https://dx.doi.org/10.2174/1573412910666140630165745 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Evaluation of Cytotoxic and Tyrosinase Inhibitory Activities of 2-phenoxy(thiomethyl) pyridotriazolopyrimidines: In Vitro and Molecular Docking Studies
Anti-Cancer Agents in Medicinal Chemistry Novel Immunotherapies for Hematological Malignancies
Current Molecular Pharmacology Erratum to Phytochemicals for the management of melanoma
Mini-Reviews in Medicinal Chemistry Resveratrol Enhances UVA-Induced DNA Damage in HaCaT Human Keratinocytes
Medicinal Chemistry Indolo[3,2-b]quinolines: Synthesis, Biological Evaluation and Structure Activity-Relationships
Mini-Reviews in Medicinal Chemistry Urokinase-a Very Popular Cardiovascular Agent
Recent Patents on Cardiovascular Drug Discovery Multimodal Optical, X-Ray CT, and SPECT Imaging of a Mouse Model of Breast Cancer Lung Metastasis
Current Molecular Medicine Nano-Based Therapy for Treatment of Skin Cancer
Recent Patents on Anti-Infective Drug Discovery ABC Transporters in Extrahepatic Tissues: Pharmacological Regulation in Heart and Intestine
Current Medicinal Chemistry Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy
Current Medicinal Chemistry Rapid Estrogen Signaling in Spermatogenesis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy
Current Drug Targets Preventive and Therapeutic Effects of the Retinoid X Receptor Agonist Bexarotene on Tumors
Current Drug Metabolism Capillary Electrophoresis Study on DNA-Protein Complex Formation in the Polymorphic 5 Upstream Region of the Dopamine D4 Receptor (DRD4) Gene
Current Medicinal Chemistry Epigenetic Therapies of Cancer
Current Cancer Therapy Reviews The Role of ABC Transporters in Drug Resistance, Metabolism and Toxicity
Current Drug Delivery Microtubule Targeting Agents: A Benchmark in Cancer Therapy
Current Drug Therapy Design, Synthesis and Biological Evaluation of Some Novel Thiazole-2- Carboxamide Derivatives as Antitumor Agents
Letters in Drug Design & Discovery Targeting Kinase Interaction Networks: A New Paradigm in PPI Based Design of Kinase Inhibitors
Current Topics in Medicinal Chemistry Carbohydrate-Metal Complexes and their Potential as Anticancer Agents
Current Medicinal Chemistry