A Facile Synthesis of Differently Protected Cystathionines in Aqueous Solutions

Author(s): Lei Zhang, Xiangming Zhu

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 10 , 2014

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A simple method for the synthesis of differently protected cystathionines is described. Reaction of γ- bromohomoalanine with cysteine derivatives in an ethyl acetate/water two-phase system, which contains TBAHS and NaHCO3, led to the desired protected cystathionines in very high to excellent yields. Apart from the high yields, the mild conditions and the ease of conducting the reactions are also attractive features for this procedure.

Keywords: Cystathionine, thioether, protecting group, phase-transfer catalysis.

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Article Details

Year: 2014
Published on: 04 September, 2014
Page: [1000 - 1003]
Pages: 4
DOI: 10.2174/0929866521666140626110653
Price: $65

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