Neoglycopeptide Synthesis by Suzuki-Miyaura Couplings between Glycosyl Aryl Boronic Acids and Iodopeptides

Author(s): Guohua Chen, Xiangying Gu, Lin Chen, Xin Wang, Yue-Lei Chen, Jingkang Shen, Wenbin Zeng

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 10 , 2014


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Abstract:

Suzuki-Miyaura coupling reaction was applied in the syntheses of neoglycopeptides. This work utilizes new type of glycosyl aryl boronic acid and readily accessible iodo amino acids/iodopeptides. Both carbohydrate and peptide moieties are unprotected and the final product could be isolated directly. The neoglyco amino acid and neoglycopeptide products feature an O-glycosyl biaryl linker between the carbohydrate and peptide moieties.

Keywords: Glycosyl aryl boronic acids, glycopeptides, iodo peptides, neoglycopeptides, Suzuki-Miyaura coupling.

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Article Details

VOLUME: 21
ISSUE: 10
Year: 2014
Published on: 04 September, 2014
Page: [1004 - 1010]
Pages: 7
DOI: 10.2174/0929866521666140626103204
Price: $65

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