Abstract
Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most common neurodegenerative disorders and affect more than 35 million people. Due to the limited effectiveness of available treatments in halting the neurodegenerative process, new therapies, such therapies based on growth factors (GFs), have been investigated. Nevertheless, the efficacies of these new treatments depend not only on the application of neurotrophins but also on the approaches used to deliver these proteins such that they can reach the brain. This review summarises the most widely used drug delivery systems (DDSs) for releasing GFs as possible treatments for AD and PD.
Keywords: Alzheimer’s disease, central nervous system, drug delivery systems, GDNF, Parkinson’s disease, VEGF.
Mini-Reviews in Medicinal Chemistry
Title:Novel Drug Delivery Systems for Releasing Growth Factors to the CNS: Focus on Alzheimer`s and Parkinson`s Diseases
Volume: 14 Issue: 7
Author(s): E. Herran, M. Igartua, J.L. Pedraz and R.M. Hernandez
Affiliation:
Keywords: Alzheimer’s disease, central nervous system, drug delivery systems, GDNF, Parkinson’s disease, VEGF.
Abstract: Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most common neurodegenerative disorders and affect more than 35 million people. Due to the limited effectiveness of available treatments in halting the neurodegenerative process, new therapies, such therapies based on growth factors (GFs), have been investigated. Nevertheless, the efficacies of these new treatments depend not only on the application of neurotrophins but also on the approaches used to deliver these proteins such that they can reach the brain. This review summarises the most widely used drug delivery systems (DDSs) for releasing GFs as possible treatments for AD and PD.
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Herran E., Igartua M., Pedraz J.L. and Hernandez R.M., Novel Drug Delivery Systems for Releasing Growth Factors to the CNS: Focus on Alzheimer`s and Parkinson`s Diseases, Mini-Reviews in Medicinal Chemistry 2014; 14 (7) . https://dx.doi.org/10.2174/1389557514666140622205058
DOI https://dx.doi.org/10.2174/1389557514666140622205058 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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