Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure

Author(s): Konstantinos Tziomalos, Asterios Karagiannis, Vasilios G. Athyros

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 40 , 2014

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In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.

Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.

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Article Details

Year: 2014
Published on: 14 October, 2014
Page: [6306 - 6313]
Pages: 8
DOI: 10.2174/1381612820666140622201452
Price: $65

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