Title:Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure
VOLUME: 20 ISSUE: 40
Author(s):Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros
Affiliation:Aristotle University, First Propedeutic Department of Internal Medicine, AHEPA Hospital, 1 Stilponos Kyriakidi street, 546 36, Thessaloniki, Greece.
Keywords:Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
Abstract:In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways.
We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution
of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic
and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous
thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation,
thrombosis or blood pressure play a role in their antiatherogenic potential.
