In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways.
We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution
of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic
and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous
thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation,
thrombosis or blood pressure play a role in their antiatherogenic potential.
Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
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